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Results for S-Adenosyl-Methionine (SAM-e)

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Total votes: 10
Average rating: 3.2 (out of 6)
Vote for S-Adenosyl-Methionine (SAM-e)
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Latest Comments

5 Point Comments - It Helped Me a Lot

Sat, 20 Oct 2018 20:12:00
Helps with liver issues. 400-800 mgs/day.

Fri, 23 Aug 2013 23:09:26
Psychiatrist credits it with an improvement in depression, and I think it has reduced my overall chronic pain levels

All 5 point comments for S-Adenosyl-Methionine (SAM-e) - 2 (20%)

4 Point Comments - It Helped Me a Bit

Thu, 28 Nov 2013 18:04:52
Seems to help a bit if I take a lot of it. Although it is quite expensive.

Thu, 28 Nov 2013 02:26:03
Initially, it had a distinct energizing effect, with an immediate improvement in mood and ability to form thoughts. That was not from thinking differently, it was an effect of the substance. It relieved brain fog for several hours. If taken late in the afternoon it significantly interfered with sleep.

After about 2 weeks, it stops working for me and must be discontinued for a while. Recently it seems to have a milder effect; I use 200mg tablets, one or, ideally, two per day about 5 hours apart.
I would give this a 4/5 rating: When it works, it can be quite useful, though the amount of the effect varies and diminishes after the initial boost. Taking more than your system wants may lead to jittery, useless energy.

All 4 point comments for S-Adenosyl-Methionine (SAM-e) - 2 (20%)

3 Point Comments - It Made No Difference

Fri, 24 Jun 2016 02:21:21
It made no difference.

Mon, 18 Jan 2016 03:09:10
It made no difference.

All 3 point comments for S-Adenosyl-Methionine (SAM-e) - 3 (30%)

2 Point Comments - It Made Me a Bit Worse

Fri, 08 May 2015 03:02:55
Didn't induce serotonin syndrome (which 5-HTP did, for me), but I felt odd and weirdly uncomfortable on it.

Tue, 21 Aug 2012 23:48:19
I think it increased excitotoxicity symptoms.

All 2 point comments for S-Adenosyl-Methionine (SAM-e) - 2 (20%)

1 Point Comments - It Made Me a Lot Worse

Wed, 31 Oct 2012 19:01:11
Terrible mood fluctuations toward despair and crying incessantly with untoward amounts of anxiety. Not consistent at all throughout the day. Tried various dosing guidelines and all felt bad to me.

All 1 point comments for S-Adenosyl-Methionine (SAM-e) - 1 (10%)